The fracture intervention trial

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FRAX estimates the 10-year probability of major osteoporotic fracture. Clodronate and bazedoxifene reduced non-vertebral and clinical fracture more effectively on a relative scale in women with higher FRAX scores. We used data from the Fracture Intervention Trial (FIT) to evaluate the interaction between FRAX score and treatment with alendronate. We combined the Clinical Fracture (CF) arm and Vertebral Fracture (VF) arm of FIT. The CF and VF arm of FIT randomized 4432 and 2027 women respectively to placebo or alendronate for 4 and 3 years respectively. FRAX risk factors were assessed at baseline. FRAX scores were calculated by WHO……..

Donaldson M, Palermo L, Ensrud K, Hochberg M, Schousboe J, Cummings S. Effect 
of alendronate for reducing fracture by FRAX score and femoral neck BMD: The
fracture intervention trial. J Bone Miner Res. 2012 Apr 10. doi:
10.1002/jbmr.1625. [Epub ahead of print] PubMed PMID: 22492479.
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